Rapid Neurological Recovery Post Thrombolysis: Mechanisms and Implications

Rapid Neurological Recovery Post Thrombolysis: Mechanisms and Implications

Intravenous thrombolysis improves long term functional outcomes in acute ischemic stroke. A select proportion of patients treated with thrombolysis experience rapid early neurological recovery, a powerful predictor of favourable long term outcomes. There is increased interest to augment early neurological recovery by endovascular therapy or by adjuvant intravenous thrombolytics. However, incomp...

Mechanisms of unexplained neurological deterioration after intravenous thrombolysis.

BACKGROUND AND PURPOSE Unstable clinical course characterizes the first 24 hours after thrombolysis for anterior circulation stroke, including early neurological deterioration (END), a secondary complication consistently predictive of poor outcome. Apart from straightforward causes, such as intracerebral hemorrhage and malignant edema, the mechanism of END remains unclear in the majority of cas...

Fibrogenesis: Mechanisms, Dynamics and Clinical Implications

Fibrosis is the pathological condition resulting in the growth of excess fibrous connective tissue in an organ or body system as a reparative or reactive process. In the field of clinical pathology, clinicians and medical scientists are endeavoring to translate experimental knowledge into effective, innovative treatments for a range of fibrotic conditions. The amelioration of whole organ functi...

Deep Moonquake Focal Mechanisms: Recovery and Implications

Characteristics and outcome of patients with early complete neurological recovery after thrombolysis for acute ischemic stroke.

BACKGROUND Recombinant tissue plasminogen activator (rt-PA) is the only approved specific therapy for acute ischemic stroke. This study analyzes demographic and clinical characteristics of patients with early complete neurological recovery after thrombolysis. METHODS Data of 320 consecutive patients treated with rt-PA within 3 h of stroke onset at our facility between April 2006 and March 200...